Towards atomic detail of intermediate filament structure
نویسندگان
چکیده
منابع مشابه
Picornavirus uncoating intermediate captured in atomic detail
It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into the host cell. Picornaviruses are simple models for such viruses, and initiate this uncoating process through particle expansion, which reveals channels through which internal capsid proteins and the viral genome presumably exit the particle, although this has not been clearl...
متن کاملAtomic structure of the vimentin central α-helical domain and its implications for intermediate filament assembly.
Together with actin filaments and microtubules, intermediate filaments (IFs) are the basic cytoskeletal components of metazoan cells. Over 80 human diseases have been linked to mutations in various IF proteins to date. However, the filament structure is far from being resolved at the atomic level, which hampers rational understanding of IF pathologies. The elementary building block of all IF pr...
متن کاملStructure of the Intermediate Filament-Binding Region of Desmoplakin
Desmoplakin (DP) is a cytoskeletal linker protein that connects the desmosomal cadherin/plakoglobin/plakophilin complex to intermediate filaments (IFs). The C-terminal region of DP (DPCT) mediates IF binding, and contains three plakin repeat domains (PRDs), termed PRD-A, PRD-B and PRD-C. Previous crystal structures of PRDs B and C revealed that each is formed by 4.5 copies of a plakin repeat (P...
متن کاملPlasticity of Intermediate Filament Subunits
Intermediate filaments (IFs) assembled in vitro from recombinantly expressed proteins have a diameter of 8-12 nm and can reach several micrometers in length. IFs assemble from a soluble pool of subunits, tetramers in the case of vimentin. Upon salt addition, the subunits form first unit length filaments (ULFs) within seconds and then assembly proceeds further by end-to-end fusion of ULFs and sh...
متن کاملThe atomic detail of an evaporating meniscus
Atomistic simulations of a simple Lennard-Jones fluid are used to investigate the very near-wall dynamics and thermodynamics of evaporating menisci. The specific configuration considered is a two-dimensional sin the meand liquid drop centered on a cold spot on an atomically smooth solid wall with evaporating menisci extending from it onto hotter regions of the wall. In the four cases simulated,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2006
ISSN: 0108-7673
DOI: 10.1107/s0108767306097212